Born Frances Eleanor Clark on January 19, 1773 in Caroline County, Virginia to Jonathan Christopher Clark and Ann Rogers Clark. Her brother was General George Rogers Clark
First married February 21, 1791 in Jefferson, Kentucky to Dr. James O'Fallon. From this union was born at least John Benjamin O'Fallon.
Second married January 19, 1796 to Charles Mynn Thruston. From this union was born at least Anne Clark Thruston and Charles William Thruston.
Third Married May 13, 1805 to her cousin Dennis Fitzhugh in Jefferson, Kentucky. From this union was born at least Clark and Lucy Fitzhugh. Passed away June 16, 1825 at the home of her son Colonel John O'Fallon in St Louis, Missouri.