Edward Wyatt was two years old when his father brought him to Jamestown, Virginia in 1621. He returned to England with his parents in 1625.

Later in 1642, his uncle, Sir Francis Wyatt, the first royal governor of Virginia, at that time Governor of Virginia for a second term, brought Edward Wyatt and his brothers and sisters back to Virginia.

Edward and his brother, George Wyatt had land grants to plantations where the town of Williamburg, Virginia now stands. The National Geographic Magazine in an issue about Williamsburg, Virginia. mentions the fact that when the capital of the Virginia Colony was to be placed at Williamsburg, that the House of Burgess and the Crown bought the land from Edward and George Wyatt.

Edward Wyatt then removed to Gloucester County, Virginia and settled on a plantation that he called Boxley. He had several children, Conquest, Francis, Haute and Edward. Edward died young and is buried at old Petsworth Episcopal Church Cemetery with his father and mother in Virginia.